Which gene expression is associated with Ankylosing Spondylitis?

Which gene expression is associated with Ankylosing Spondylitis?

• A. HLA A2
• B. HLA B27
• C. HLA DR4
• D. HLA Cw6

Answer: (B)

The association of Ankylosing Spondylitis (AS) with HLA B27 is well-documented in clinical research. HLA B27 is a human leukocyte antigen which plays a significant role in the immune system and has been found to be present in a large proportion of individuals with AS. Studies indicate that approximately 90-95% of patients with Ankylosing Spondylitis express the HLA B27 antigen compared to about 6-8% of the general population. This substantial correlation suggests that HLA B27 may confer susceptibility to the disease, implicating it in the pathogenesis of AS. The association with HLA B27 has led researchers to explore its role in the immune response and inflammation, key factors in the development and progression of Ankylosing Spondylitis. HLA B27 is thought to trigger abnormal immune responses, possibly due to molecular mimicry or other mechanisms, which can lead to inflammation of the sacroiliac joints and spine characteristic of AS. In contrast, the other gene expressions mentioned are associated with different autoimmune conditions or have a lesser association with Ankylosing Spondylitis specifically. HLA A2 and HLA DR4 are linked to other types of autoimmune diseases but

The association of Ankylosing Spondylitis (AS) with HLA B27 is well-documented in clinical research. HLA B27 is a human leukocyte antigen which plays a significant role in the immune system and has been found to be present in a large proportion of individuals with AS. Studies indicate that approximately 90-95% of patients with Ankylosing Spondylitis express the HLA B27 antigen compared to about 6-8% of the general population. This substantial correlation suggests that HLA B27 may confer susceptibility to the disease, implicating it in the pathogenesis of AS.

The association with HLA B27 has led researchers to explore its role in the immune response and inflammation, key factors in the development and progression of Ankylosing Spondylitis. HLA B27 is thought to trigger abnormal immune responses, possibly due to molecular mimicry or other mechanisms, which can lead to inflammation of the sacroiliac joints and spine characteristic of AS.

In contrast, the other gene expressions mentioned are associated with different autoimmune conditions or have a lesser association with Ankylosing Spondylitis specifically. HLA A2 and HLA DR4 are linked to other types of autoimmune diseases but